Base de dados : HANSEN Pesquisa : HANSENIASE VIRCHOWIANA/SANGUE [Descritor de assunto] Referências encontradas : 6 [refinar] Mostrando: 1 .. 6   no formato [Detalhado]

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Id: 27299 Autor: Klatser, Paul R; Janson, Anneke M; Thole, Jelle E. R; Buhrer, Samira; Bos, Corinne; Soebono, Hardyanto; Vries, Rene R. P. de. Título: Humoral and cellular immune reactivity to recombinant M. leprae antigens in HLA-Typed leprosy patients and healthy controls. Fonte: Int. J. Lepr;65(2):178-189, Jun. 1997. tab, graf. Resumo: In our search for Mycobacterium leprae antigens that might specifically induce immunity or immunopathology, we have tested both humoral and cellular immune reactivity against purified recombinant M. leprae antigens in 29 paucibacillary (PB), 26 multibacillary (MB) leprosy patients, and 47 matched healthy contacts. The following M. leprae antigens were tested: 2L-1 (65L-1, GroEl-1), 2L-2 (65L-2, GroEl-2), 4L (SoDA), 43L, 10L (B) and 25L (Sra). The individuals were also typed for HLAD-RB1 and DQB1 in order to see whether leprosy status and/or immune reactivity to these antigens might be associated with certain HLA types. We also tested sera from another 48 patients before, during and after multidrug therapy (MDT) to study the relationship between antibody reactivity to recombinant M. leprae antigens and MDT. Antibody titers to the four recombinant M. leprae antigens tested and to D-BSA were higher in MB patients compared to PB patients and healthy controls, and declined with treatment. From a diagnostic or monitoring point of view none of the recombinant antigens seemed to be an improvement over D-BSA, mainly due to the lower sensitivity. IgG subclasses were measured in positive sera of untreated patients. These were mainly of the IgG1 and IgG3 subclasses, but subclass diversity was also observed and antigen dependent: all four subclasses could be detected against 10L (B), only IgG1 and IgG3 against 43L and only IgG1 against 25L and 2L-1. Cellular immune reactivity against the purified recombinant M. leprae antigens was measured in a lymphocyte stimulation test (LST). As for M. leprae, there was an inverse correlation between antibody and T-cell reactivity. However, the number of LST responders to recombinant antigens was much lower than to M. leprae. The 43L antigen was recognized most often (19%-24% of individuals tested) and more often than the 10L (B) antigen (10%-12%). No clear correlation was observed with leprosy type or protection and, in general, M. leprae nonresponders were also negative with recombinant antigens. Finally, we confirmed that HLA-DRB1*02 is associated with leprosy in this population, and we observed an association between DQB1*0601 and lepromatous leprosy. The number of positive individuals was too small to allow a meaningful analysis of the relationship between HLA type and immune reactivity. Although these data do not allow a conclusion as to one of these purified recombinant antigens being either protection or disease related, the antigen-dependent IgG subclass diversity warrants further study on antigen-specific qualitative differences in immune reactivity that may be relevant for the outcome of an infection with M. leprae. (AU)^ien. Descritores: Hanseníase Dimorfa/sangue Hanseníase Dimorfa/imunol Hanseníase Virchowiana/sangue Hanseníase Virchowiana/imunol Hanseníase Tuberculóide/sangue Hanseníase Tuberculóide/imunol Localização: BR191.1

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Id: 27274 Autor: Memon, Riaz Z; Kifayet, Arnawaz; Shahid, Firdaus; Lateef, Anisa; Chiang, Thomas J; Hussain, Rabia. Título: Low serum HDL-cholesterol is associated with raised tumor necrosis factor-alpha during ENL reactions. Fonte: Int. J. Lepr;65(1):1-11, Mar., 1997. tab, graf. Resumo: The concentrations of serum lipids and tumor necrosis factor (TNF) were measured in leprosy patients across the spectrum of the disease and in erythema nodosum leprosum (ENL) patients at the onset of the reaction and after the reaction had clinically subsided. Lepromatous/borderline lepromatous (LL/BL) patients had significantly higher serum triglyceride and lower HDL-cholesterol levels; there was no such change in the tuberculoid/borderline tuberculoid (TT/BT) patients. The household contacts (HC) of the LL/BL patients also had significantly lower serum HDL levels. ENL patients during the acute phase of the reaction had significantly lower total, LDL-, HDL-cholesterol levels compared to the stable LL/BL patients, and these changes were reversible to pre-ENL levels after the reaction had subsided. Serum TNF levels were significantly higher in household contacts and in LL/BL patients but were not statistically different in TT/BT patients. Serum TNF levels were also significantly higher during the acute phase of ENL, and declined after the clinical remission of the reaction to levels comparable with those of LL/BL patients. There was a significant negative correlation between serum TNF and HDL-cholesterol levels during and after ENL reaction. However, there was no such correlation between TNF and total or LDL-cholesterol levels in ENL patients. Our results suggest that the changes in HDL-cholesterol metabolism are a specific part of the host response to lepromatous leprosy and to the ENL reaction and may be mediated by increased TNF production. (AU)^ien. Descritores: Hanseníase Virchowiana/sangue Hanseníase Tuberculóide/sangue Colesterol HDL/anal Colesterol HDL/sangue Colesterol HDL/metab Colesterol LDL/anal Colesterol LDL/sangue Colesterol LDL/metab Limites: Humanos Masculino Feminino Adolescente Adulto Meia-Idade Localização: BR191.1

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Id: 25985 Autor: Belda, Walter. Título: Tratamento do mal perfurante plantar com um extrato de sangue desproteinizado (Solcoseryl): primeiros resultados. Fonte: Rev. bras. Leprol;33(1/4):61-67, jan.-dez. 1965. ^bilus. Resumo: Após considerações gerais sobre a importância do problema do mal perfurante plantar como incapacidade f¡sica e sua gênese, o autor expõe as caracter¡sticas de um produto obtido do sangue de amimais jovens (Solcoseryl) e usado no tratamento desta complicação tardia de lepra. Em quatorze anos obtem doze curas com um m¡nimo de cinco e um máximo de 38 aplicações, e em dois casos obtem melhora evidente. Os resultados são ilustrados por fotografias anteriores e posteriores ao tratamento. Concluiu-se que, pela ação cicatrizante rápida, é de utilidade no tratamento, em regime ambulatorial, do mal perfurante plantar de origem leprótica. (AU)^ipt. Descritores: Úlcera do Pé/sangue Úlcera do Pé/cirurg Hanseníase Dimorfa/sangue Hanseníase Dimorfa/fisiopatol Hanseníase Dimorfa/cirurg Hanseníase Virchowiana/sangue Hanseníase Virchowiana/fisiopatol Hanseníase Virchowiana/cirurg Hanseníase Tuberculóide/sangue Hanseníase Tuberculóide/fisiopatol Limites: Humanos Masculino Feminino Adulto Meia-Idade Idoso Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/brasleprol/1965/PDF/v33n1-4/v33n1-4a07.pdf - pt. Localização: BR191.1

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Id: 25409 Autor: Matthews, L. J; Trautman, J. R Título: Clinical and serological profiles in leprosy ?- Fonte: s.l; s.n; 1965. 4p p. tab. Resumo: Numerous clinical and serological similarities exist between lepromatous and dimorphous leprosy and diseases od collagen, particularly lupus erythematosus and rheumatoid arthritis. The clinical manifestations include spontaneous skin-ulcerations, ischaemic necrosis, petechial and purpuric eruptions, vesicle and bulla formation, subcutaneous nodules, hepatosplenomegaly, migratory arthralgia and polyarthritis, bizarre skin lesions including butterfly facial rashes, and a general tendency toward exacerbations and remissions. Haematological findings include anaemia and the ocasional appearance of lupus cells.Positive serological findings include rheumatoid factors, circulating thyroglobulin antibodies, false positive serological tests for syphilis, and cold precipitable proteins (a consistent finding). Because of these similarities, the authors believe that leprosy is a disease which should be considered as a model for the study of hyperglobulinaemic states, especially the diseases of collagen. An important consideration is that, unlike these other diseases, the agent causing leprosy is known. Descritores: HANSENIASE DIMORFA/sangue HANSENIASE DIMORFA/diag HANSENIASE VIRCHOWIANA/sangue HANSENIASE VIRCHOWIANA/diag SEROLOGIA/métodos SEROLOGIA/estatíst SEROLOGIA/tend - TIROGLOBULINA/anal  TIROGLOBULINA/sangue  SORODIAGNOSTICO DA SIFILIS Limites: HUMANO Localização: BR191.1; 01815/s

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Id: 25086 Autor: Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae Título: Differential production of interleukin-10 and interleukin-12 mononuclear cells from leprosy patients with a Toll-like receptor 2 mutations ..- Fonte: s.l; s.n; 2004. 7 p. tab, graf. Resumo: Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infections with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Argo677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in Il-4 production between the mutant and wild-type during stimulation. Yhus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy pateints and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy (AU). Descritores: HANSENIASE VIRCHOWIANA/sangue HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/diag HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/sangue HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol INTERLEUCINA-10/anal INTERLEUCINA-10/sangue INTERLEUCINA-10/imunol INTERLEUCINA-12/anal INTERLEUCINA-12/sangue INTERLEUCINA-12/imunol - LEUCOCITOS MONONUCLEARES/imunol  IMUNOCOMPETÊNCIA/imunol Limites: ESTUDO COMPARATIVO HUMANO Localização: BR191.1; 09194/s

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Id: 20625 Autor: Ermakóva, Nína. Título: Studies on leprosy. II. Formation, distribution and diagnostic significance of pigment. Fonte: Int. J. Lepr;4(4):445-454, Oct.-Dec. 1936. ilus. Resumo: An iron-containing blood pigment was found in the affected organs and tissues of all cases of leprosy that I examined. In the nodular form of the disease this pigment is deposited in strikingly large quantities, while in the maculo-neural and tuberculoid forms the quantity is very small. The cause of the pigment formation may be (a)erythrocyte destruction in the general blood stream, or (b) some process of local character. The generally accepted view that the leprosy bacillus does not excrete toxic substances that may act on the cells of the organisms seems to be against the first of these theories. However, this view is based entirely on clinical data and not on experimental immuno-biological studies. It seems quite possible that products of bacillary activity may be fixed by the lipoid membrane of the erythrocyte and destroy them. In favor of the second theory, that the pigment is of local origin, is my observation that erythrophagocytosis is found with some constancy in the lesions. It is true that in cases of the nodular form phagocytosis is demonstrated with great difficulty, though the pigment is deposited in large quantities. However, in some of the cases in which there were lesser quantities of pigment, that did not interfere with the clearness of the picture, phagocytosis could be observed. At any rate, the question must be regarded as an open one, requiring further study... (AU). Descritores: HANSENIASE/clas HANSENIASE/diag HANSENIASE/patol HANSENIASE VIRCHOWIANA/sangue HANSENIASE VIRCHOWIANA/patol HANSENIASE TUBERCULOIDE/sangue HANSENIASE TUBERCULOIDE/patol HANSENIASE/sangue HANSENIASE/compl - PELE  NERVOS PERIFERICOS/patol  BACO/patol  FIGADO/patol  GÔNADAS/patol  LINFONODOS/patol  HEMOSSIDERINA Limites: HUMANO necropsia biopsia Localização: BR191.1

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